Arsenal, Chelsea and Manchester City were all handed trips to League One sides hoping to cause an upset in the Carabao Cup third round draw.
Mikel Arteta's Arsenal have been paired with Darren Moore's Port Vale, Chelsea go to Lincoln City, while Pep Guardiola's Man City face a trip to Huddersfield.
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Elsewhere in the draw, Grimsby Town - who stunned Ruben Amorim's Manchester United at Blundell Park on Wednesday night - were rewarded with a trip to Championship side Sheffield Wednesday, who knocked out Leeds on Tuesday despite the Owls' troubles.
There is also a spicy local derby with Crystal Palace hosting Millwall - in an exact repeat of last season's FA Cup tie that saw Jean-Philippe Mateta seriously injured by now-former goalkeeper Liam Roberts.
Liverpool will host Championship side Southampton, while holders Newcastle are at home to Bradford in round three. Thomas Frank's Spurs will host another League One side in Doncaster Rovers.
There are also two all-Premier League clashes in Brentford vs Aston Villa and Wolves vs Everton.
Carabao Cup third round matches in full
Matches to be played on w/c September 15:
Sheffield Wednesday vs Grimsby Town
Wolves vs Everton
Crystal Palace vs Millwall
Burnley vs Cardiff
Wrexham vs Reading
Wigan Athletic vs Wycombe
Barnsley vs Brighton
Fulham vs Cambridge
Matches to be played on w/c September 22:
Port Vale vs Arsenal
Swansea City vs Nottingham Forest
Lincoln City vs Chelsea
Tottenham Hotspur vs Doncaster
Brentford vs Aston Villa
Huddersfield Town vs Manchester City
Liverpool vs Southampton
Newcastle vs Bradford City
